24/06/2024 - Sakina MHAOUTY-KODJA : Plasticizers, brain and behavior

LES LUNDIS DE SAINT-ANTOINE

Bâtiment Kourilsky - 11h–12h

Salle des Conférences (Rez de Chaussée),

184 rue du Faubourg Saint-Antoine, Paris

***

24 JUIN 2024

Plasticizers, brain and behavior

Sakina MHAOUTY-KODJA

DR1 CNRS, Equipe Neuroplasticité des comportements de reproduction, Neurosciences Paris-Seine, IBPS (Sorbonne Université, CNRS, Inserm)

invité par véronique BEREZIAT équipe de Bruno FEVE

(veronique.bereziat@sorbonne-universite.fr)

Phthalates are among the most frequently detected organ pollutants in the environment. They are used in the manufacture and processing of polyvinyl chloride plastic, cosmetic and personal care products, cleaning products, etc. Di-2-ethylhexyle phthalate, dibutyl phthalate, benzyl butyl phthalate and other substances of this family were identified as endocrine disruptors due to their ability to reduce fetal testosterone production and impair reproductive male function (European Chemical Agency, European Food Safety agency). In this context, the effects of phthalate exposure on the neuroendocrine control of reproduction and cognition in males and females, in particular at environmentally relevant doses, received little attention.
This presentation aims to give an overview of the most recent data from the team, describing the effects and neuroendocrine mode of action of exposure to environmentally relevant doses of phthalates on reproductive and cognitive behaviors. The obtained results will be presented and discussed in the context of risk assessment of these substances for human health and environment.

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